GO7923: MRFF – CTA Initiative – 2025 Clinical Trials Activity Grant Opportunity

The Medical Research Future Fund (MRFF) Clinical Trials Activity Initiative aims to: improve the evidence base supporting clinical care help patients access trials relevant to their health circumstances enable researchers to bring international trials to Australian patients.

The objective of this grant opportunity is to provide grants of financial assistance to support medical research and medical innovation projects that: Stream 1 (Incubator): conduct a pilot study to assess the feasibility of a new clinical trial for one or more treatments and/or management strategies for a rare cancer, rare disease and/or unmet need.

Stream 2 (Targeted Call for Research): conduct a clinical trial of one or more treatments and/or management-based interventions for rare cancers, rare diseases and/or unmet need.

Stream 3 (Targeted Call for Research): conduct a clinical trial that supports the delivery of effective and high value care by targeting evidence gaps of value to health technology assessment processes in Australia.

Stream 4 (Targeted Call for Research): conduct a prevention clinical trial aimed at reducing the risk, onset or progression of disease through early intervention strategies.

The intended outcome of the research is to improve the health and wellbeing of Australians by investing in new clinical trials that support increased access to high-quality, evidence-based and effective health care.

Applicants to this grant opportunity must propose research that addresses one of the four Streams of research.

This grant opportunity is being administered by NHMRC on behalf of the Australian Government Department of Health, Disability and Ageing.

Further information on the Medical Research Future Fund is available fromthe Department of Health, Disability and Ageing's website.

A list of Eligible Organisations can be found on the NHMRC List of MRFF Eligible Organisations webpage

To be eligible the applicant organisation must be an MRFF Eligible Organisation approved by NHMRC.

Joint (consortia) applications are allowed provided there is a lead organisation that is eligible.

Applicants must nominate a Chief Investigator A (CIA) who will lead the application; a CIA generally must be an Australian citizen or permanent resident at time of application submission (or have requisite work visa in place at time of accepting grant) and must be based in Australia for the duration of the grant (excluding reasonable overseas travel).

A person must not be named as a Chief Investigator on more than one application submitted to a Stream (maximum one application per person per Stream).

Up to 15 Chief Investigators may be named.

Applications must comply with all other requirements in the guidelines (including budget limits per Stream, formatting, minimum data submission and RAO certification and submission by the advertised closing date/time).